PROCEEDINGS BOOK
WELCOME
Dear Colleagues and Friends,
As Presidents of the 6th ASPIC International Congress, and on behalf of the Organizing and Scientific Committees, it is with great enthusiasm that we invite you to attend this congress, which will be held on April 29th and 30th, at the University of Algarve, Campus de Gambelas, Faro, Portugal.
This is the first time that ASPIC is organizing its international congress outside Lisbon and Porto and we are very happy and confident about our choice. Faro is a welcoming city, with a warm climate and people, and with excellent cancer research groups. ASPIC is very grateful to the University of Algarve for hosting us in 2024 and we promise another rewarding meeting and an exceptional opportunity to share basic, translational, and clinical data, as well as to develop networking with professionals involved in cancer research.
The Congress Scientific Programme will feature lectures performed by invited speakers from ASPIC, ASEICA, and EACR, as well as four symposiums that cover a broad range of topics led by selected experts sharing their knowledge and most recent advances, including selected oral presentations from the abstracts submitted. We also expect a big and participative Poster Session.
You are invited to take an active part in this conference, which we believe will be an outstanding scientific event. We hope that you will take the opportunity to benefit from the exciting scientific programme and from new contacts and collaborations. During the meeting, there will be great opportunities for young scientists to meet the experts in the field, and we aim to create an open and engaging environment for discussion.
We look forward to welcoming you at the fantastic city of Faro.
Joana Paredes, Ana-Teresa Maia and Fernando Schmitt
(Presidents of the 6th ASPIC International Congress)
Scientific & Organizing Commitee
Joana Paredes
Ana-Teresa Maia
Bibiana Ferreira
Joana Xavier
Luisa Melo
Scientific Evaluation Committee
Chairs: Sérgio Dias and Ana Sofia Ribeiro
Ana Luísa Sousa Coelho
Bruno Costa
Célia Gomes
João Lobo
Jorge Lima
Mónica Teotónio Fernandes
Sara Ricardo
Scientific Programme
Europe/Lisbon ( GMT)
29th April, 2024
09:00h – 09:30h
Official Opening
Joana Paredes (ASPIC, i3S, Porto, PT), Ana-Teresa Maia (RISE@CINTESIS – UAlg, Faro, PT)
09:30h – 10:00h
ASPIC Lecture – Prognosis of Breast Cancer associated with the Portuguese BRCA2 founder mutation (BRCA2p)
Fátima Vaz (IPO-Lisboa, Portugal)
10:00h – 10:15h
ASPIC Lecture – POPCARE: a nation-wide platform to speed up precision medicine in pediatric oncology
Jorge Lima (Ipatimup/i3S, Porto, PT)
10:15h – 11:00h
USA-PT Lecture – Understanding & Taming Pancreas Cancer
Ronald DePinho (MDAnderson, Houston, USA)
11:00h – 11:30h
COFFEE BREAK
Symposium I – Tumour Genomics & Evolution
Chair: Joana Xavier (RISE@CINTESIS -UAlg, Faro, PT) & Jorge Lima (Ipatimup, Porto, PT)
11:30h – 12:00h
Fluctuating methylation for lineage tracing in cancer
Trevor A Graham (ICR, London, UK)
12:00h – 12:15h
Selected Oral Communication
Exploiting the Relevance of WNT6 in Extracellular Vesicles of Glioblastoma: Clinical and Molecular Insights
Helena M. Figueiredo (ICVS, Braga, PT)
12:15h – 12:45h
Leukemia Stem Cells: Seek and Destroy
Alice Giustacchini (Human Technopole, Milan, Italy)
12:45h – 13.00h
Selected Oral Communication
Sphingosine kinase activity is essential for IL-7R-mediated signaling in acute lymphoblastic leukemia, but not in healthy lymphocytes
Marta B. Fernandes (IMM, Lisbon, PT)
13:00h – 14:00h
LUNCH
14:00h – 16:00h
Poster Session
16:00h – 16:30h
COFFEE BREAK
Symposium II – Tumor Metabolism & Epigenetic Control
Chairs: Bibiana Ferreira (ABC-Ri, Faro, PT) & Carmen Jerónimo (IPOP, Porto, PT)
16:30h – 17:00h
Nutrient signaling to mTOR at the crossroads of cancer and aging
Alejo Efeyan (CNIO, Madrid, Spain)
17:00h – 17.15h
Selected Oral Communication
Lactate in the epigenetic landscape recoding: towards new therapeutic strategies in renal cell carcinoma
Vera Miranda-Gonçalves (CI-IPOP, Porto, PT)
17:15h – 17:45h
Mutagenesis, lesion segregation, and cancer genome formation
Duncan Odom (DKFZ, Heidelberg, Germany)
17:45h – 18.00h
Selected Oral Communication
Nano-immunotherapy combination to regulate immune profiling and tumor-associated stroma in pancreatic cancer
Liane Moura (iMed.ULisboa, Lisbon, PT)
18:00h – 19.00h
ASPIC General Assembly and Elections
20:00h
Congress Dinner
30th April, 2024
Plenary Lectures
Chairs: Wolfgang Link (FMCB, Faro, PT) & Sérgio Dias (IMM, Lisbon, PT)
9:00h – 09:45h
ASEICA Lecture – Understanding and predicting prostate cancer aggressiveness through the deconstruction of cell signaling and metabolism
Arkaitz Carracedo ( CICbioGUNE, Bizkaya, Spain)
09:45h – 10:30h
EACR Lecture – The metabolic cross-talk between T cells and tumor cells in melanoma-derived metastasis
Ilaria Elia (KU, Leuven, Belgium)
10:30h – 11.00h
COFFEE BREAK
Symposium III – Immunotherapies & Microenvironment
Chairs: Daniel Bandarra (CHUA, Faro, PT) & João Nuno Moreira (FFUC, Coimbra, PT)
11:00h – 11:30h
Expanding the cancer immunotherapy toolbox
Noel de Miranda (LUMC, Leiden, Netherlands)
11:30h – 11:45h
Selected Oral Communication
Immunosurveillance shapes the tumor genetic landscape selecting against putative immunogenic mutations
Helena Xavier-Ferreira (i3S, Porto, PT)
11:45h – 12:15h
Integrated multi-omic analysis of adaptive immunosurveillance in early and metastatic breast cancer
Stephen Sammut (ICR, London, UK)
12:15h – 12:30h
Selected Oral Communication
Exosomes define a local and systemic communication network in healthy pancreas and pancreatic ductal adenocarcinoma
Sónia A. Melo (i3S, Porto, PT)
12:30h – 13:30h
LUNCH
13:30h – 15:30h
Poster Session
Symposium IV – Translational Oncology
Chairs: Ana Teresa Maia (RISE@CINTESIS – UAlg, Faro, PT) & Cláudia Faria (IMM, Lisbon, PT)
15:30h – 16:00h
The immune landscape of breast cancer during pregnancy
Elena Guerini Rocco (IEO, University of Milan, Milan, Italy)
16:00h – 16:15h
Selected Oral Communication
The zAvatar-test forecasts patient’s treatment outcome in colorectal cancer: a clinical study towards personalized medicine
Bruna Costa (Champalimaud Foundation, Lisbon, PT)
16:15h – 16:45h
RANK pathway driven therapeutic opportunities in breast cancer
Sandra Casimiro (IMM, Lisbon, PT)
16:45h – 17:00h
Selected Oral Communication
A 3D tumor-on-chip platform to study intravasation
Carolina Morais (IMM, Lisbon, PT)
17:00h – 17.30h
COFFEE BREAK
17:30h – 18:00h
Awards & Closing Session
Fernando Schmitt (RISE@CINTESIS – UP, Porto, PT)